[HTML][HTML] Structure of human spindlin1: tandem Tudor-like domains for cell cycle regulation
Q Zhao, L Qin, F Jiang, B Wu, W Yue, F Xu… - Journal of biological …, 2007 - ASBMB
Spindlin1, a meiotic spindle-binding protein that is highly expressed in ovarian cancer cells,
was first identified as a gene involved in gametogenesis. It appeared to be a target for cell
cycle-dependent phosphorylation and was demonstrated to disturb the cell cycle. Here we
report the crystal structure of human spindlin1 to 2.2 Å of resolution, representing the first
three-dimensional structure from the spin/ssty (Y-linked spermiogenesis-specific transcript)
gene family. The refined structure, containing three repeats of five/four anti-parallel β …
was first identified as a gene involved in gametogenesis. It appeared to be a target for cell
cycle-dependent phosphorylation and was demonstrated to disturb the cell cycle. Here we
report the crystal structure of human spindlin1 to 2.2 Å of resolution, representing the first
three-dimensional structure from the spin/ssty (Y-linked spermiogenesis-specific transcript)
gene family. The refined structure, containing three repeats of five/four anti-parallel β …
