Introduction Murine placentation requires trophoblast Notch2, while the Notch ligand,
JAGGED1, is reduced in invasive trophoblasts from women with preeclampsia. However, the
placental cells with active Notch signaling and expression of other Notch proteins and
ligands in placentation have yet to be defined. We sought to identify endothelial cell and
trophoblast subtypes with canonical Notch signaling in the decidua and placenta and
correlate this to expression of Notch proteins and ligands. Methods Notch reporter …